Summer Student 2019: Abigail Wright
Supervised by Dr Sebastien Farnaud at Coventry University, Abigail will develop and validate an all-human model of Parkinson’s disease to replace experiments on mice, rats, dogs and monkeys.
The primary symptoms of Parkinson’s disease, including muscle rigidity, tremor and slowing of physical movement, are thought to be the result of a deficiency in dopamine – one of the brain’s chemical messengers. The cause of Parkinson’s disease is still unknown, so it is often treated by restoring dopamine levels in patients, which can alleviate the symptoms of the disease – but not what causes it. However, people with Parkinson’s disease often have increased levels of iron in their brain, which might play a role in causing less dopamine to be produced.
Parkinson’s disease does not develop naturally in any animals except humans. However, monkeys, rats, mice, dogs, cats and pigs have all, unfortunately, been experimented on in an attempt to study the disease. Animals are kept in cages and repeatedly injected with chemicals to force them to suffer with the symptoms of Parkinson’s disease. They can experience seizures, limb paralysis, tremors, collapsing and even death, before being forced into various machines and instruments to be experimented on. Animals who don’t die as a result of being drugged are killed and punctured in their hearts to flush the blood out of their bodies before their brains are removed for further dissection.
In her summer research project, Abigail will develop an all-human model of Parkinson’s disease to understand the mechanism of the disease and if iron affects it. She will validate her novel human-cell model of Parkinson’s disease by demonstrating that the dopamine level decreases when the human cells experience Parkinson’s disease. She will then study how iron effects this change in dopamine level. Her research could allow the disease mechanism of Parkinson’s disease to be discovered, potentially leading to the development of treatments that tackle the cause of the disease and helping to replace cruel animal experiments in Parkinson’s disease research.
Research is imperative to the development of the biomedical field. It allows knowledge and understanding of disease – permitting advances in diagnosis, prognosis and treatment of disease cause and its induced symptoms. As a future biomedical scientist, my summer research project will help me strive for animal free research. The development of an all-human model could provide a humane and valid animal-replacement model for studying Parkinson’s disease.
Page last modified on February 5, 2020 4:17 pm