The paper, by scientists from the University of Luxemborg, describes a robust human brain organoid system that is highly specific to the midbrain and is derived from iPSCs. This human midbrain organoid contains spatially organised groups of dopaminergic neurons, making it an attractive model for the study of Parkinson’s disease. The organoid shows  neuronal, astroglial, and oligodendrocyte differentiation and contains the presence of synaptic connections and electrophysiological activity.

Research highlights
•Generation of a human in vitro midbrain model from neural precursor cells
•Midbrain organoids show neuronal, astroglial, and oligodendrocyte differentiation
•Midbrain organoids contain spatially organized groups of dopaminergic neurons
•Detection of synaptic connections, electrophysiological activity, and myelination

Original publication:

Monzel et al., Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells, Stem Cell Reports (2017), DOI:10.1016/j.stemcr.2017.03.010