Brain tumour experts Professor Geoff Pilkington and Dr Zaynah Maherally are developing the first cutting-edge, animal free, 3D model of the blood-brain barrier to find more effective ways of treating patients, including children, who suffer from brain tumours.
This research aims to understand the mechanisms that cause particular cells of the pancreas, beta cells, to lose their ability to produce insulin in those suffering from diabetes.
Val Speirs, Professor of experimental pathology & oncology at the University of Aberdeen, is leading a three year study that hopes to identify an effective strategy for preventing breast cancer.
Every year, 8% of the population will be diagnosed with chronic pain but only two-thirds will recover. By collecting human nerve stem cells from discarded human teeth, this project will increase our understanding of how inflammation affects the nerve cells in the face and how this can lead to chronic pain, whilst replacing the use of animals.
This pioneering work with the Thiel embalming method will help to teach doctors potentially life-saving surgical interventions such as advanced abdominal aortic stent graft repair without the need to practice these methods on animals such as pigs. Heart, stroke, kidney and liver patients are among those who will benefit directly from the training clinicians will undergo.
Dr Karen Pilkington wants to assess whether human in vitro methods can be used to replace certain animal-based studies in research into brain tumours.
The ARC, at the Blizard Institute QMUL, provides a unique environment for scientists to work together to develop human-based models of skin, breast and prostate cancer, replacing mouse models. It also aims to inspire the next generation of scientists through education about animal free research.