At the Institute of Child Health at Great Ormond Street Children’s Hospital, Dr Claire Smith and her team are developing a new 3D model of the infant lung to accurately mimic the conditions of RSV bronchiolitis – a life-threatening lung infection.
At our Animal Replacement Centre of Excellence (ARC 1.0) in London, Dr Adrian Biddle and his team are embarking on a project to develop reliable animal free methods to understand how tumour cells spread and invade other organs of the human body (known as metastasis).
Professor Chris Denning and his team at the University of Nottingham are working to develop cutting edge human stem cell models, deepening our understanding of cardiac fibrosis – a prevailing cause of heart failure in the UK.
Val Speirs, Professor of experimental pathology & oncology at the University of Aberdeen, is leading a three year study that hopes to identify an effective strategy for preventing breast cancer.
This pioneering work with the Thiel embalming method will help to teach doctors potentially life-saving surgical interventions such as advanced abdominal aortic stent graft repair without the need to practice these methods on animals such as pigs. Heart, stroke, kidney and liver patients are among those who will benefit directly from the training clinicians will undergo.
Dr Karen Pilkington wants to assess whether human in vitro methods can be used to replace certain animal-based studies in research into brain tumours.
Brain tumour experts Professor Geoff Pilkington and Dr Zaynah Maherally are developing the first cutting-edge, animal free, 3D model of the blood-brain barrier to find more effective ways of treating patients, including children, who suffer from brain tumours.
The ARC, at the Blizard Institute QMUL, provides a unique environment for scientists to work together to develop human-based models of skin, breast and prostate cancer, replacing mouse models. It also aims to inspire the next generation of scientists through education about animal free research.