A novel microfluidic device to model the human proximal tubule and glomerulus
Scientists from Binghamton University in the USA have developed a re-usable multi-layer microfluidic device to model the human kidney. The model incorporates a porous growth substrate, physiological fluid flow, and also allows for the passive filtration of the glomerulus.
This kidney model showed improvements over traditional 2D and 3D cell-based models, as the cells in the device exhibited more natural behaviours and allowed for the detection of adverse toxic effects from candidate drugs in a human-relevant system.
Through the incorporation of human kidney cells into an optimized microfluidic device, it will be possible to study and understand these adverse toxic effects before they appear in human clinical trials or pre-clinical animal studies.