Nanoscale topography for stem cell maintenance and disease modelling of leukaemia

Rachel Henderson at the University of Glasgow will conduct human-relevant research into leukaemia, without harming any mice.Read more

Characterisation of a novel organotypic skin culture model

Shreya Asher will be working at Queen Mary University of London on a skin cell culture model to better understand skin cancer without having to conduct any experiments on mice.Read more

Building an adipose-rich tumour microenvironment model to study fat-cancer cross-talk

A cell culture model will allow Evie Gruszyk at Sheffield Hallam University an opportunity to understand colorectal cancer without the need to use mice.Read more

Creation of a 3D gastrointestinal culture model to study the influence of commensal bacterial on gut growth and differentiation

At Sheffield Hallam University, Oana Voloaca will use a novel gut tissue model to investigate the influence of bacteria in gastrointestinal diseases such as crohn’s disease to replace studies in rats.Read more

Prediction of Cytochrome P450 2D6 interaction from atomic structure

Taleen Shakouri from the University of Hertfordshire, will be developing a computer model of certain toxicology tests which has the potential to replace many experiments currently conducted on primates and mice.Read more

Using CRISPR-Cas9 to correct mutations in hiPSC from patients with schizophrenia who have mutations in DLG2

Edward Nendick at the University of Edinburgh will be using one of the latest cutting edge, gene editing technologies, CRISPR-Cas9, in cell culture to further our understanding of schizophrenia without using mice.Read more

Development of Thrombus Model for Thiel cadaveric training model

Using Thiel-embalmed cadavers at the University of Dundee, Emma-Jane Macrae will develop a ‘clot model’ for heart diseases to replace the use of pigs.Read more

Development of human cell co-culture for respiratory diseases

Joy Girgis at the University of Hertfordshire will use human cell culture to develop novel testing methods in lung disease studies to replace rodent studies.Read more

Refining an all-human model for Atopic Dermatitis

Using explant cell culture to replace mice studies, Bronte Munro at the University of East Anglia will investigate the causes of atopic dermatitis and psoriasis.Read more