A selection of Animal Free Research UK projects showing how they are developing techniques to replace the use of animal in biomedical research.
For a full list of projects please go to 'Our Projects' via the 'Our Research' dropdown link above.
Stem cells are unspecialised cells that have the extraordinary potential to either proliferate through mitosis to produce more stem cells or to differentiate, under certain physiological or experimental conditions, into more specialised cells such as brain or muscle cells.Read more
‘Organs-on-a-chip’ are the next exciting development in in 3D cell culture. These are ‘organs’ made up of real, living human cells which mimic a real organ system.Read more
Cell culture is the term given to the method by which cells are grown outside of their natural environment in a laboratory setting. The 2 main types of cell culture are 2D and 3D cell culture.Read more
This research on schwannomas and meningiomas used a unique human cell culture model using cells derived from surgical patients. This has led to the identification and testing of new, targeted therapies and the team have successfully translated their research into early clinical trials. This approach has allowed them to screen approved drugs directly and go straight into clinical trials, avoiding pre-clinical animal trials.Read more
Every year, 8% of the population will be diagnosed with chronic pain but only two-thirds will recover. By collecting human nerve stem cells from discarded human teeth, this project will increase our understanding of how inflammation affects the nerve cells in the face and how this can lead to chronic pain, whilst replacing the use of animals.Read more
This pioneering work with the Thiel embalming method will help to teach doctors potentially life-saving surgical interventions such as advanced abdominal aortic stent graft repair without the need to practice these methods on animals such as pigs. Heart, stroke, kidney and liver patients are among those who will benefit directly from the training clinicians will undergo.Read more