Summer Studentships 2017

Building an adipose-rich tumour microenvironment model to study fat-cancer cross-talk

A cell culture model will allow Evie Gruszyk at Sheffield Hallam University an opportunity to understand colorectal cancer without the need to use mice.

Pasta la vista: a potential biomaterial for regenerative medicine

Joanitta Akpai from the University of Hertfordshire will be working on developing novel biomaterials from pasta to create 3D cell culture models to help to replace the use of rodents in vascular disease and cancer research.

Modelling stroke and heart disease in cadavers to replace pigs

Using Thiel-embalmed cadavers at the University of Dundee, Emma-Jane Macrae has developed a ‘clot model’ to train doctors in treating stroke and heart diseases, without using pigs.

Cell culture model of osteoarthritis to replace guinea pigs, rats and rabbits

Alexander Lanz, at the University of Sheffield, will be developing a cell culture model of osteoarthritis, to replace current experiments on guinea pigs, rats and rabbits.

Switching to human stem cells to study leukaemia

Rachel Henderson at the University of Glasgow conducted human-relevant research into leukaemia, without harming any mice.

Pinning down the proteins of Parkinson’s disease

Lauren Richardson from Nottingham Trent University researched Parkinson’s disease using advanced cell culture and proteomics (the study of the proteins of a cell). This will help to replace the use of primates, rats or mice.

Breath of fresh air for lung disease

Joy Girgis at the University of Hertfordshire used human cell culture to develop novel testing methods in lung disease studies to replace rodent studies.

Characterisation of a novel organotypic skin culture model

Shreya Asher will be working at Queen Mary University of London on a skin cell culture model to better understand skin cancer without having to conduct any experiments on mice.

Creation of a 3D gastrointestinal culture model to study the influence of commensal bacterial on gut growth and differentiation

At Sheffield Hallam University, Oana Voloaca will use a novel gut tissue model to investigate the influence of bacteria in gastrointestinal diseases such as crohn’s disease to replace studies in rats.

Prediction of Cytochrome P450 2D6 interaction from atomic structure

Taleen Shakouri from the University of Hertfordshire, will be developing a computer model of certain toxicology tests which has the potential to replace many experiments currently conducted on primates and mice. Project sponsored by Raj Saubhag.

Using CRISPR-Cas9 to correct mutations in hiPSC from patients with schizophrenia who have mutations in DLG2

Edward Nendick at the University of Edinburgh will be using one of the latest cutting edge, gene editing technologies, CRISPR-Cas9, in cell culture to further our understanding of schizophrenia without using mice.

Refining an all-human model for Atopic Dermatitis

Using explant cell culture to replace mice studies, Bronte Munro at the University of East Anglia will investigate the causes of atopic dermatitis and psoriasis.

Characterization of cancer stem cell sub-populations in melanoma

Stephanie Lunt will be working at Queen Mary University of London using patient cancer samples to identify biomarkers in skin cancer (melanoma) to help replace the use of mice.

The role of skin structure in protecting against pressure ulcers

At Imperial College London, Sergi Fayos Villalta will be doing a computational modelling project looking at the development of pressure ulcers and soft tissue damage to replace the use of mice and rats. Project sponsored by Raj Saubhag.

Evaluation of the quantity and quality of RNA extracted from formalin fixed paraffin embedded prostate cancer tissue samples

To replace the use of many animals in prostate cancer research and testing, Diliany Oliveira from the University of Portsmouth will be developing a non-animal based screening tool to detect cancer biomarkers.