A cell culture model will allow Evie Gruszyk at Sheffield Hallam University an opportunity to understand colorectal cancer without the need to use mice.
Joanitta Akpai from the University of Hertfordshire will be working on developing novel biomaterials from pasta to create 3D cell culture models to help to replace the use of rodents in vascular disease and cancer research.
Using Thiel-embalmed cadavers at the University of Dundee, Emma-Jane Macrae has developed a ‘clot model’ to train doctors in treating stroke and heart diseases, without using pigs.
Alexander Lanz, at the University of Sheffield, will be developing a cell culture model of osteoarthritis, to replace current experiments on guinea pigs, rats and rabbits.
Rachel Henderson at the University of Glasgow conducted human-relevant research into leukaemia, without harming any mice.
Lauren Richardson from Nottingham Trent University researched Parkinson’s disease using advanced cell culture and proteomics (the study of the proteins of a cell). This will help to replace the use of primates, rats or mice.
Joy Girgis at the University of Hertfordshire used human cell culture to develop novel testing methods in lung disease studies to replace rodent studies.
Shreya Asher will be working at Queen Mary University of London on a skin cell culture model to better understand skin cancer without having to conduct any experiments on mice.
Creation of a 3D gastrointestinal culture model to study the influence of commensal bacterial on gut growth and differentiation
At Sheffield Hallam University, Oana Voloaca will use a novel gut tissue model to investigate the influence of bacteria in gastrointestinal diseases such as crohn’s disease to replace studies in rats.
Taleen Shakouri from the University of Hertfordshire, will be developing a computer model of certain toxicology tests which has the potential to replace many experiments currently conducted on primates and mice. Project sponsored by Raj Saubhag.
Using CRISPR-Cas9 to correct mutations in hiPSC from patients with schizophrenia who have mutations in DLG2
Edward Nendick at the University of Edinburgh will be using one of the latest cutting edge, gene editing technologies, CRISPR-Cas9, in cell culture to further our understanding of schizophrenia without using mice.
Using explant cell culture to replace mice studies, Bronte Munro at the University of East Anglia will investigate the causes of atopic dermatitis and psoriasis.
Stephanie Lunt will be working at Queen Mary University of London using patient cancer samples to identify biomarkers in skin cancer (melanoma) to help replace the use of mice.
At Imperial College London, Sergi Fayos Villalta will be doing a computational modelling project looking at the development of pressure ulcers and soft tissue damage to replace the use of mice and rats. Project sponsored by Raj Saubhag.
Evaluation of the quantity and quality of RNA extracted from formalin fixed paraffin embedded prostate cancer tissue samples
To replace the use of many animals in prostate cancer research and testing, Diliany Oliveira from the University of Portsmouth will be developing a non-animal based screening tool to detect cancer biomarkers.